Plaque Rupture, Lysophosphatidic Acid, and Thrombosis
نویسندگان
چکیده
منابع مشابه
Plaque rupture, lysophosphatidic acid, and thrombosis.
How does rupture of an atherosclerotic plaque activate platelets, and what can be done to lessen the risk of an ensuing thrombotic episode? Several important new observations that may provide answers to these vital questions are described by Rother et al1 in the present issue of Circulation. This group previously reported that lysophosphatidic acid (LPA), a phospholipid that activates platelets...
متن کامل4 Atherosclerotic plaque rupture
The arterial system is more than an intricate plumbing system for the transport of blood; it is a highly complex organ that interacts with its environment. The major function of the vessel wall, and more specifically the endothelial lining, is to maintain an adequate blood supply to the end organ that it is supplying. This is achieved by regulatory mechanisms that control vascular tone, inflamm...
متن کاملAtherosclerotic Plaque Rupture
The idiom “the straw that breaks the camel’s back” describes scenarios where seemingly minor incidents eventuate in a sudden, unexpected, and often detrimental downfall. In the case of atherosclerosis, over time multiple subclinical cellular events result in the development of unstable, vulnerable atherosclerotic lesions, which leads to the rupture of atherosclerotic plaques, culminating in the...
متن کاملAtherosclerotic Plaque Rupture
It is generally established that the unstable plaque is the major cause of acute clinical sequelae of atherosclerosis. Unfortunately, terms indicating lesions prone to plaque instability, such as “vulnerable plaque,” and the different phenotypes of unstable plaques, such as plaque rupture, plaque fissuring, intraplaque hemorrhage, and erosion, are often used interchangeably. Moreover, the diffe...
متن کاملNeointimal cracks (plaque rupture?) and thrombosis in wrapped arteries without flow.
The Editor’s pick for the June 2006 issue of Arteriosclerosis, Thrombosis, and Vascular Biology was the article by Sasaki et al1 entitled “A Simple Method of Plaque Rupture Induction in Apolipoprotein E–Deficient Mice.” The key term in this title is “plaque rupture.” The article was accompanied by a supportive editorial by Jackson.2 We would like to suggest that the enthusiasm for this experime...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 2003
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000082307.85449.1d